# Scientific Research Paper Critique Example Paper

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This paper by Amrhein et al. criticizes a paper by Bradley Efron that discusses Bayesian statistics (Efron, 2013a), focusing on a particular example that was also discussed in Efron (2013b). The example concerns a woman who is carrying twins, both male (as determined by sonogram and we ignore the possibility that gender has been observed incorrectly). The parents-to-be ask Efron to tell them the probability that the twins are identical.

This is my first open review, so I'm not sure of the protocol. But given that there appears to be errors in both Efron (2013b) and the paper under review, I am sorry to say that my review might actually be longer than the article by Efron (2013a), the primary focus of the critique, and the critique itself. I apologize in advance for this. To start, I will outline the problem being discussed for the sake of readers.

This problem has various parameters of interest. The primary parameter is the genetic composition of the twins in the mother’s womb. Are they identical (which I describe as the state x = 1) or fraternal twins (x = 0)? Let y be the data, with y = 1 to indicate the twins are the same gender. Finally, we wish to obtain Pr(x = 1 | y = 1), the probability the twins are identical given they are the same gender1. Bayes’ rule gives us an expression for this:

Pr(x = 1 | y = 1) = Pr(x=1) Pr(y = 1 | x = 1) / {Pr(x=1) Pr(y = 1 | x = 1) + Pr(x=0) Pr(y = 1 | x = 0)}

Now we know that Pr(y = 1 | x = 1) = 1; twins must be the same gender if they are identical. Further, Pr(y = 1 | x = 0) = 1/2; if twins are not identical, the probability of them being the same gender is 1/2.

Finally, Pr(x = 1) is the prior probability that the twins are identical. The bone of contention in the Efron papers and the critique by Amrhein et al. revolves around how this prior is treated. One can think of Pr(x = 1) as the population-level proportion of twins that are identical for a mother like the one being considered.

However, if we ignore other forms of twins that are extremely rare (equivalent to ignoring coins finishing on their edges when flipping them), one incontrovertible fact is that Pr(x = 0) = 1 − Pr(x = 1); the probability that the twins are fraternal is the complement of the probability that they are identical.

The above values and expressions for Pr(y = 1 | x = 1), Pr(y = 1 | x = 0), and Pr(x = 0) leads to a simpler expression for the probability that we seek ‐ the probability that the twins are identical given they have the same gender:

Pr(x = 1 | y = 1) = 2 Pr(x=1) / [1 + Pr(x=1)] (1)

We see that the answer depends on the prior probability that the twins are identical, Pr(x=1). The paper by Amrhein et al. points out that this is a mathematical fact. For example, if identical twins were impossible (Pr(x = 1) = 0), then Pr(x = 1| y = 1) = 0. Similarly, if all twins were identical (Pr(x = 1) = 1), then Pr(x = 1| y = 1) = 1. The “true” prior lies somewhere in between. Apparently, the doctor knows that one third of twins are identical2. Therefore, if we assume Pr(x = 1) = 1/3, then Pr(x = 1| y = 1) = 1/2.

Now, what would happen if we didn't have the doctor's knowledge? Laplace's “Principle of Insufficient Reason” would suggest that we give equal prior probability to all possibilities, so Pr(x = 1) = 1/2 and Pr(x = 1| y = 1) = 2/3, an answer different from 1/2 that was obtained when using the doctor's prior of 1/3.

Efron (2013a) highlights this sensitivity to the prior, representing someone who defines an uninformative prior as a “violator”, with Laplace as the “prime violator”. In contrast, Amrhein et al. correctly points out that the difference in the posterior probabilities is merely a consequence of mathematical logic. No one is violating logic – they are merely expressing ignorance by specifying equal probabilities to all states of nature. Whether this is philosophically valid is debatable (Colyvan 2008), but this example does not lend much weight to that question, and it is well beyond the scope of this review. But setting Pr(x = 1) = 1/2 is not a violation; it is merely an assumption with consequences (and one that in hindsight might be incorrect2).

Alternatively, if we don't know Pr(x = 1), we could describe that probability by its own probability distribution. Now the problem has two aspects that are uncertain. We don’t know the true state x, and we don’t know the prior (except in the case where we use the doctor’s knowledge that Pr(x = 1) = 1/3). Uncertainty in the state of x refers to uncertainty about this particular set of twins. In contrast, uncertainty in Pr(x = 1) reflects uncertainty in the population-level frequency of identical twins. A key point is that the state of one particular set of twins is a different parameter from the frequency of occurrence of identical twins in the population.

Without knowledge about Pr(x = 1), we might use Pr(x = 1) ~ dunif(0, 1), which is consistent with Laplace. Alternatively, Efron (2013b) notes another alternative for an uninformative prior: Pr(x = 1) ~ dbeta(0.5, 0.5), which is the Jeffreys prior for a probability.

Here I disagree with Amrhein et al.; I think they are confusing the two uncertain parameters. Amrhein et al. state:

“We argue that this example is not only flawed, but useless in illustrating Bayesian data analysis because it does not rely on any data. Although there is one data point (a couple is due to be parents of twin boys, and the twins are fraternal), Efron does not use it to update prior knowledge. Instead, Efron combines different pieces of expert knowledge from the doctor and genetics using Bayes’ theorem.”

This claim might be correct when describing uncertainty in the population-level frequency of identical twins. The data about the twin boys is not useful by itself for this purpose – they are a biased sample (the data have come to light because their gender is the same; they are not a random sample of twins). Further, a sample of size one, especially if biased, is not a firm basis for inference about a population parameter. While the data are biased, the claim by Amrheim et al. that there are no data is incorrect.

However, the data point (the twins have the same gender) is entirely relevant to the question about the state of this particular set of twins. And it does update the prior. This updating of the prior is given by equation (1) above. The doctor’s prior probability that the twins are identical (1/3) becomes the posterior probability (1/2) when using information that the twins are the same gender. The prior is clearly updated with Pr(x = 1| y = 1) ≠ Pr(x = 1) in all but trivial cases; Amrheim et al.’s statement that I quoted above is incorrect in this regard.

This possible confusion between uncertainty about these twins and uncertainty about the population level frequency of identical twins is further suggested by Amrhein et al.’s statements:

“Second, for the uninformative prior, Efron mentions erroneously that he used a uniform distribution between zero and one, which is clearly different from the value of 0.5 that was used. Third, we find it at least debatable whether a prior can be called an uninformative prior if it has a fixed value of 0.5 given without any measurement of uncertainty.”

Note, if the prior for Pr(x = 1) is specified as 0.5, or dunif(0,1), or dbeta(0.5, 0.5), the posterior probability that these twins are identical is 2/3 in all cases. Efron (2013b) says the different priors lead to different results, but this result is incorrect, and the correct answer (2/3) is given in Efron (2013a)3. Nevertheless, a prior that specifies Pr(x = 1) = 0.5 does indicate uncertainty about whether this particular set of twins is identical (but certainty in the population level frequency of twins). And Efron’s (2013a) result is consistent with Pr(x = 1) having a uniform prior. Therefore, both claims in the quote above are incorrect.

It is probably easiest to show the (lack of) influence of the prior using MCMC sampling. Here is WinBUGS code for the case using Pr(x = 1) = 0.5.

model { pr_ident_twins <- 0.5 # prior probability that the twins are identical x ~ dbern(pr_ident_twins) # are they identical? If so, x = 1, and 0 otherwise pr_same_gender <- x + (1-x)*0.5 # the probability that the twins have the same gender. It equals 1 if x = 1, and 0.5 otherwise (i.e., if x = 0) same_gender <- 1 # the single data point - the twins are the same gender same_gender ~ dbern(pr_same_gender) # those data arise as a Bernoulli sample with probability pr_same_gender } Running this model in WinBUGS shows that the posterior mean of x is 2/3; this is the posterior probability that x = 1.

Instead of using pr_ident_twins <- 0.5, we could set this probability as being uncertain and define pr_ident_twins ~ dunif(0,1), or pr_ident_twins ~ dbeta(0.5,0.5). In either case, the posterior mean value of x remains 2/3 (contrary to Efron 2013b, but in accord with the correction in Efron 2013a).

Note, however, that the value of the population level parameter pr_ident_twins is different in all three cases. In the first it remains unchanged at 1/2 where it was set. In the case where the prior distribution for pr_ident_twins is uniform or beta, the posterior distributions remain broad, but they differ depending on the prior (as they should – different priors lead to different posteriors4). However, given the biased sample size of 1, the posterior distribution for this particular parameter is likely to be misleading as an estimate of the population-level frequency of twins.

So why doesn’t the choice of prior influence the posterior probability that these twins are identical? Well, for these three priors, the prior probability that any single set of twins is identical is 1/2 (this is essentially the mean of the prior distributions in these three cases).

If, instead, we set the prior as dbeta(1,2), which has a mean of 1/3, then the posterior probability that these twins are identical is 1/2. This is the same result as if we had set Pr(x = 1) = 1/3. In both these cases (choosing dbeta(1,2) or 1/3), the prior probability that a single set of twins is identical is 1/3, so the posterior is the same (1/2) given the data (the twins have the same gender).

Further, Amrhein et al. also seem to misunderstand the data. They note:

“Although there is one data point (a couple is due to be parents of twin boys, and the twins are fraternal)...”

This is incorrect. The parents simply know that the twins are both male. Whether they are fraternal is unknown (fraternal twins being the complement of identical twins) – that is the question the parents are asking. This error of interpretation makes the calculations in Box 1 and subsequent comments irrelevant.

Box 1 also implies Amrhein et al. are using the data to estimate the population frequency of identical twins rather than the state of this particular set of twins. This is different from the aim of Efron (2013a) and the stated question.

Efron suggests that Bayesian calculations should be checked with frequentist methods when priors are uncertain. However, this is a good example where this cannot be done easily, and Amrhein et al. are correct to point this out. In this case, we are interested in the probability that the hypothesis is true given the data (an inverse probability), not the probabilities that the observed data would be generated given particular hypotheses (frequentist probabilities). If one wants the inverse probability (the probability the twins are identical given they are the same gender), then Bayesian methods (and therefore a prior) are required. A logical answer simply requires that the prior is constructed logically. Whether that answer is “correct” will be, in most cases, only known in hindsight.

However, one possible way to analyse this example using frequentist methods would be to assess the likelihood of obtaining the data for each of the two hypothesis (the twins are identical or fraternal). The likelihood of the twins having the same gender under the hypothesis that they are identical is 1. The likelihood of the twins having the same gender under the hypothesis that they are fraternal is 0.5. Therefore, the weight of evidence in favour of identical twins is twice that of fraternal twins. Scaling these weights so they sum to one (Burnham and Anderson 2002), gives a weight of 2/3 for identical twins and 1/3 for fraternal twins. These scaled weights have the same numerical values as the posterior probabilities based on either a Laplace or Jeffreys prior. Thus, one might argue that the weight of evidence for each hypothesis when using frequentist methods is equivalent to the posterior probabilities derived from an uninformative prior. So, as a final aside in reference to Efron (2013a), if we are being “violators” when using a uniform prior, are we also being “violators” when using frequentist methods to weigh evidence? Regardless of the answer to this rhetorical question, “checking” the results with frequentist methods doesn’t give any more insight than using uninformative priors (in this case). However, this analysis shows that the question can be analysed using frequentist methods; the single data point is not a problem for this. The claim in Armhein et al. that a frequentist analyis "is impossible because there is only one data point, and frequentist methods generally cannot handle such situations" is not supported by this example.

In summary, the comment by Amrhein et al. raises some interesting points that seem worth discussing, but it makes important errors in analysis and interpretation, and misrepresents the results of Efron (2013a). This means the current version should not be approved.

References

Burnham, K.P. & D.R. Anderson. 2002. Model Selection and Multi-model Inference: a Practical Information-theoretic Approach. Springer-Verlag, New York.

Colyvan, M. 2008. Is Probability the Only Coherent Approach to Uncertainty? Risk Anal. 28: 645-652.

Efron B. (2003a) Bayes’ Theorem in the 21st Century. Science 340(6137): 1177-1178.

Efron B. (2013b) A 250-year argument: Belief, behavior, and the bootstrap. Bull Amer. Math Soc. 50: 129-146.

Footnotes

• The twins are both male. However, if the twins were both female, the statistical results would be the same, so I will simply use the data that the twins are the same gender.
• In reality, the frequency of twins that are identical is likely to vary depending on many factors but we will accept 1/3 for now.
• Efron (2013b) reports the posterior probability for these twins being identical as “a whopping 61.4% with a flat Laplace prior” but as 2/3 in Efron (2013a). The latter (I assume 2/3 is “even more whopping”!) is the correct answer, which I confirmed via email with Professor Efron. Therefore, Efron (2013b) incorrectly claims the posterior probability is sensitive to the choice between a Jeffreys or Laplace uninformative prior.
• When the data are very informative relative to the different priors, the posteriors will be similar, although not identical.

## How to Critique an Article

Every day students get dozens of new assignments of all shapes and kinds, so it is more that simple to get lost in all of the rules and guidelines. One of such tasks is a critique and often we are asked ‘what is an article critique’, as it is not a regular task and has some specific structural and content requirements.

If you want to learn how to critique an article, you should first have a clear understanding of what this assignment is about. Generally, it is an objective analysis of any piece of work (not depending on its genre), which includes your personal thoughts on the subject. You need to give the reader an idea of whether the author of an article based it on facts and credible information. Your main goal is to show your personal opinion, backed with evidence and arguments, so you need to be very attentive while reading the article and noting down key elements.

Many students fail to complete this task, as they simply provide a summary of the analyzed paper, forgetting about personal approach and challenging your own skills and knowledge. That is why it is so simple to make one of many mistakes, while completing an article critique. These mistakes may include:

• Using only negative critique. Although your main aim is to analyze the article, you should add some positive features to dilute the overall impressive from your paper;
• Excessive background information. Most of the readers already know what the article is about or who its author is, so don’t waste too much time and energy on providing boring information on the subject itself and biography or publishing details;
• Not including the main argument. Many students forget about this important element and simply try to summarize the whole article. However, main argument is an essential part of your work and you need to include it at the beginning of your paper to make sure everyone knows what your position on the subject is.

If you follow all the recommendations, you will easily complete an outstanding article critique without any efforts!

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## Article Critique Example

One of the ways of simplifying the whole process of completing the assignment is using an article critique example. Many students decide to download such samples in order to get an overall idea of how the assignment should look like and what key points should be added.

Using an example may greatly help you to create a proper structure, use necessary formatting methods and shape the whole work according to professor’s demands. It is your way of making the whole process of creating an article critique simple and fun, following all the common rules and regulations. With the help of such samples you will be able to save lots of times and nerves, which will definitely contribute to the overall results.

### APA Format Article Critique

It is not a secret that most of professors pay careful attention not only to the content of the assignment but also how well it is formatted. That is why you need to be very attentive, when shaping your work and adding final changes. One of the most popular formatting styles, while completing an article critique is American Psychological Association (APA) format, which has its specific rules and guidelines. Your paper should be double-spaced, using 1-inch margins and Times New Roman font in 12 point. The general structure of your critique should consist of a title page, abstract, body and references. When formatting the title page, you should indicate name of your paper and school, as well as your personal data.

Article Critique APA

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Examples of Article Critiques

APA format article critique follows a clear structure:

• Abstract. This section should consist of a brief summary of the critique you are going to provide. Write down how it will influence the reader and what analysis methods were used. This paragraph should be 15-250 words long with centered word ‘Abstract’ at the top;
• Body. On the next page center the title of your work and start providing necessary details, not forgetting to double space the text. Here you should include mistakes you have found in the article, methods you have used and so on;
• References. This section may include only the paper you are analyzing but you shouldn’t forget about the formatting style you are going to use. Write the reference in such an order: last name of the author, initials, publication year, title of the article, name of the journal in italics, volume, page numbers if necessary.

In-text citations should be made using the author-date system, which means that you only need to indicate name of the author, followed by the year of publication. If you want to quote a certain part of the paper, you need to include the page name at the end.

If you know how to write an article critique, you will easily complete the assignment not depending on its complexity and formatting peculiarities.